If you’re researching supplements to support healthy blood sugar and insulin response, you’ve probably seen dozens of products promising fast results. Blood Sugar Support Plus positions itself as a science-forward, organ-based supplement designed to “restore your insulin response” using grass-fed bovine pancreas plus a blend of well-known botanicals and nutrients. In this review I’ll break down what’s inside, what the science actually says about the key ingredients, who might benefit, safety points to consider and whether this supplement is worth trying if your goal is better daily glucose control.
Table of Contents
Quick takeaway
Blood Sugar Support Plus combines a beef-pancreas enzyme extract (including amylase, lipase, protease) with clinically studied ingredients such as berberine, gymnema, cinnamon, banaba extract, vitamin D3, magnesium and vitamin K2. Several of those ingredients have human trials showing improvements in fasting glucose, A1C or glucose handling — particularly berberine, gymnema, cinnamon and banaba. However, organ-based pancreas supplements are less well-studied for reversing insulin resistance and carry practical safety considerations. If you want a natural adjunct to diet and medication (with your doctor’s approval) this formula contains many evidence-backed pieces — but don’t view it as a guaranteed substitute for medical care.

What is Blood Sugar Support Plus?
Blood Sugar Support Plus is a daily capsule supplement that combines freeze-dried, grass-fed beef pancreas (providing digestive enzymes like amylase, lipase and protease) with a multi-nutrient blend: berberine, gymnema sylvestre, cinnamon, banaba extract (corosolic acid), vitamin D3, vitamin K2, magnesium and several trace minerals. The product claims to “repair the pancreas” and restore healthy insulin response and recommends taking two capsules daily (usually before breakfast). The manufacturer emphasizes pasture-raised sourcing and third-party testing.
What’s inside — ingredient by ingredient
Below I summarize the active ingredients and the human evidence that supports (or questions) their blood-sugar benefits.
Berberine
Berberine is one of the most studied plant compounds for blood sugar. Several clinical trials and reviews have reported that berberine can lower fasting glucose and A1C and in some small trials its effect appeared comparable to metformin. This makes berberine one of the stronger single-ingredient candidates in the formula.
Gymnema sylvestre
Gymnema is an herb used traditionally in India and has clinical data showing reductions in fasting glucose, post-prandial glucose and A1C in multiple trials and meta-analyses. It’s also reported to blunt sugar cravings — a useful benefit when you’re trying to improve diet.
Cinnamon
Several trials have found that daily cinnamon (even as little as ~1 g/day) can improve fasting glucose and lipid markers in people with type 2 diabetes, although results vary by trial and cinnamon type. It’s a low-risk, well-known adjunct.
Banaba extract (corosolic acid)
Banaba and its active corosolic acid have clinical evidence of lowering blood glucose and improving insulin response within hours of dosing in some studies. Reported reductions in some trials range from modest to substantial, depending on dose and formulation.
Vitamin D3 & Vitamin K2
Vitamin D status is associated with glucose metabolism in observational studies and some trials suggest benefits for markers of insulin sensitivity — though randomized trials are mixed. Vitamin K2 has emerging evidence linking it to metabolic health and the product’s inclusion provides a nutritional foundation rather than a primary glucose-lowering effect.
Magnesium
Magnesium deficiency is common among people with type 2 diabetes and can impair insulin signaling; supplementing magnesium has been associated with improvements in metabolic markers in some studies. Including magnesium is reasonable for general metabolic support.
Pancreas enzymes (amylase, lipase, protease) — beef pancreas
The product’s standout claim is the inclusion of freeze-dried bovine pancreas — essentially delivering animal-derived digestive enzymes and pancreatic tissue extracts. There is some observational research linking low serum amylase to metabolic dysfunction and digestive enzymes play roles in nutrient breakdown and metabolic signaling. However, strong clinical trials showing that oral pancreatic organ extracts “repair” the human pancreas or restore insulin secretion in type 2 diabetes are lacking; the safety and efficacy of oral pancreas supplements for glucose control are not well established. If you are taking prescribed diabetes medication, you should discuss use with your clinician to avoid interactions or a false sense of security.
The science: evidence-backed ingredients vs. novel claims
One strength of Blood Sugar Support Plus is that many of its individual ingredients (berberine, gymnema, cinnamon, banaba, magnesium) have human clinical data showing beneficial effects on glucose control. Those are the evidence anchors in the formula. The more novel claim — that freeze-dried bovine pancreas enzymes will travel in the bloodstream and rebuild your pancreas overnight — is not supported by robust human clinical trials. Pancreatic enzymes typically act in the gut to aid digestion; evidence that oral pancreas extracts directly regenerate pancreatic beta-cells or replace prescription care is limited. In short: expect some ingredients to plausibly support glycemic control, but be cautious about absolute reversal claims.
Sourcing & quality — what to look for
This product emphasizes grass-fed, pasture-raised sourcing and third-party purity testing. Those are useful quality signals when choosing supplements; look for: third-party certificates (USP, NSF or equivalent), a clear ingredient label with doses per capsule and an expiration/manufacturing date. Also confirm the form of each nutrient (for magnesium, the specific salt matters for absorption; for cinnamon, Ceylon vs. cassia matters for coumarin content). If you have allergies or dietary restrictions, check the product’s allergen statement.
How to use Blood Sugar Support Plus
According to the product information, the recommendation is two capsules daily, typically before breakfast. For supplements that affect blood glucose, start slowly and monitor your response. If you’re on glucose-lowering medication, check blood sugar more often and coordinate dosing changes only with your healthcare provider — supplements can amplify medication effects and cause hypoglycemia if not managed properly.

Possible benefits you might notice
Customers and ingredients’ trial data report outcomes such as:
- Improved fasting glucose and lower A1C (ingredients like berberine, gymnema, cinnamon, banaba).
- Reduced sugar cravings (gymnema).
- Better digestion after meals (digestive enzymes may help with bloating/indigestion).
- Modest improvements in lipids and energy when combined with lifestyle changes.
Keep in mind that individual responses vary; the best results usually come when supplements are combined with diet, activity and medical oversight.
Safety & side effects — what you should know
While many ingredients are generally well tolerated, some important caveats:
- Berberine can interact with several medications and may cause gastrointestinal upset; don’t combine it with prescription medications without medical advice.
- Cinnamon (cassia) in high doses contains coumarin which can affect the liver in sensitive individuals; Ceylon cinnamon is lower in coumarin.
- Pancreas extracts and enzyme supplements have limited safety data for long-term use; some sources advise caution, especially if you have digestive conditions, allergies or are on multiple medications. Don’t replace prescribed insulin or oral diabetes medication without a clinician’s guidance.
Bottom line: discuss this supplement with your healthcare provider, especially if you take prescription diabetes medications, blood thinners or have chronic health conditions.
Who should consider Blood Sugar Support Plus?
- Adults with prediabetes or type 2 diabetes looking for an evidence-backed adjunct (not a replacement) to diet, exercise and medical care.
- People who prefer supplements that combine botanical actives with basic nutrients (vitamin D, magnesium, K2).
- Individuals without major medical contraindications who will monitor blood sugar regularly and keep their clinician informed.
It may be less appropriate for pregnant/nursing people, those with severe liver/kidney disease or anyone who cannot get medical follow-up.
Final verdict — is it worth trying?
Blood Sugar Support Plus stacks several ingredients that have real clinical backing for supporting glucose metabolism — berberine, gymnema, cinnamon and banaba stand out. The inclusion of magnesium and vitamins D3/K2 adds nutritional value for metabolic health. However, the product’s most dramatic claim (that bovine pancreas extract will “repair” your pancreas and restore insulin response rapidly) is not yet strongly supported by conclusive human trials. If you’re looking for a multi-ingredient supplement with a mix of traditional and modern evidence, this formula is reasonable — provided you use it as an adjunct to proven lifestyle measures and your prescribed medications.
If you decide to try it, monitor blood glucose and any symptoms closely and prioritize products with transparent third-party testing and clear dosing.
How to decide — checklist before you buy
- Are you clear on current medications and ready to discuss supplement use with your clinician?
- Does the product label list doses and third-party testing?
- Will you monitor blood glucose and keep a symptom log?
- Are you planning to combine the supplement with diet and activity changes?
If you can answer yes to those, Blood Sugar Support Plus contains multiple ingredients with a scientific rationale and may be worth a trial as part of a broader, clinically supervised plan.


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